Job Description

Job Title: Winter, Spring 2026 Co-op-Intern - Investigative Toxicology Grade: Co-op Intern LL Location: Cambridge, MA About The Job Are you ready to push the frontiers of existing immune/vascular co-culture models? Join us in an exciting, hands-on role where you will be involved in advancing immune-mediated drug-induced vascular injury (iDIVI) models for investigative toxicology. At the intersection of pharmaceutical innovation and immune cell engagement, your work will address a high unmet need within the industry. In this role, you will collaborate closely with scientists from Sanofi’s Investigative Toxicology group to expand the applications of an in vitro model of iDIVI. Moving beyond traditional 2D models, you will test drugs in a medium-throughput vascular microphysiological system (MPS) model that successfully recreates the interaction of lymphocytes with vascular endothelium. Importantly, this work will explore various classes of drugs (including small molecules, biologics, and other modalities) to capture toxicity and dissect mechanism of action. Your goal? Co-culture lymphocytes from healthy and diseased human donors in a 3D vasculature chip to test a platform that sensitively detects iDIVI, provide new insights into the outcomes of drug exposure, and delineate mechanism of toxicity. This is your chance to be at the forefront of validating a translational tool that could lead to deeper mechanistic understanding and enhanced safety for future novel therapies. We are an innovative global healthcare company with one purpose: to chase the miracles of science to improve people’s lives. We’re also a company where you can flourish and grow your career, with countless opportunities to explore, make connections with people, and stretch the limits of what you thought was possible. Ready to get started? Main Responsibilities: Collaborate with top-tier scientists to advance cutting-edge microfluidic cell culture systems. Optimize the iDIVI model with an eye toward investigative toxicology and safety assessments. Gain valuable experience with primary cell cultures, complex in-vitro models, HTS imaging (epifluorescence and confocal) and analysis, western blotting, gene expression, cytokine analysis, and in vitro barrier assessment assays. About You Must be permanently authorized to work in the U.S. and not require sponsorship of an employment visa (e.g., H-1B or green card) at the time of application or in the future. Students currently on CPT, OPT, or STEM OPT usually require future sponsorship for long term employment and do not meet the requirements for this program unless eligible for an alternative long-term status that does not require company sponsorship Basic Qualifications: Currently enrolled and pursuing a master’s degree or PhD in biology, biomedical engineering, pharmacology, toxicology, immunology or a related field at an accredited college or university with the expectation that you will complete your current degree by the Spring of 2028. Experienced in primary mammalian cell culture (required). Must be able to relocate to the office location and work 40hrs/week, Monday-Friday, for the full duration of the co-op/internship Preferred Qualifications: You’re a passionate researcher with a curious mind, eager to contribute and grow in a dynamic environment. You thrive in a collaborative, matrixed setting and bring strong written and verbal communication skills to the table. Proficiency in confocal microscopy, flow cytometry, and cytokine analysis would be a plus. If you're driven by curiosity, innovation, and the desire to make an impact in the world of drug development, this is the co-op experience for you. Join us in advancing iDILI models and developing tomorrow's therapies today! Why Choose Us: Bring the miracles of science to life alongside a supportive, future-focused team. Discover endless opportunities to grow your talent and drive your career, whether it’s through a promotion or lateral move, at home or internationally. Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact. Exposure to cutting-edge technologies and research methodologies. Networking opportunities within Sanofi and the broader biotech community. Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law. null

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